Rv2029c - phosphofructokinase pfkB

Expression: Most Significant Conditions for Rv2029c

Protein Domains

Gene Information
Locus	Rv2029c
Symbol	pfkB
Gene Name	phosphofructokinase pfkB
Location	2275405 - 2276424 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1020 bp Protein:340 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33131
Related Genes	Mkms_3475 Mmcs_3412 MSMEG_3947 MT2088 Mvan_1394 Mvan_4105 nfa52470 SAV1511
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2029c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2029c Transcript 1
MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRYDPGGGGINVARIVHV
LGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRESFTVNESRTAKQYRFVLPG
PSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSG
GGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGAL
LATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKSVRLGNAAGAAMLLTPG
TAACNRDDVERFFELAAEPTEVGQDQYVWHPIVNPEASP*

Genomic Sequence

>Rv2029c
ATGACGGAGCCAGCGGCGTGGGACGAAGGCAAGCCGCGAATCATCACTTTGACCATGAAC
CCCGCCTTGGACATCACGACGAGCGTCGACGTGGTGCGCCCGACCGAGAAAATGCGTTGT
GGCGCACCTCGCTACGATCCCGGCGGCGGCGGTATCAATGTCGCCCGCATTGTGCATGTC
CTCGGCGGTTGCTCGACAGCACTGTTCCCGGCCGGCGGGTCGACCGGGAGCCTGCTGATG
GCGCTGCTCGGTGATGCGGGAGTGCCATTTCGCGTCATTCCGATCGCGGCCTCGACGCGG
GAGAGCTTCACGGTCAACGAGTCCAGGACCGCCAAGCAGTATCGTTTCGTGCTTCCGGGG
CCGTCGCTGACCGTCGCGGAGCAGGAGCAATGCCTCGACGAACTGCGCGGTGCGGCGGCT
TCGGCCGCCTTTGTGGTGGCCAGTGGCAGCCTGCCGCCAGGTGTGGCTGCCGACTACTAT
CAGCGGGTTGCCGACATCTGCCGCCGATCGAGCACTCCGCTGATCCTGGATACATCTGGT
GGCGGGTTGCAGCACATTTCGTCCGGGGTGTTTCTTCTCAAGGCGAGCGTGCGGGAACTG
CGCGAGTGCGTCGGATCCGAACTGCTGACCGAGCCCGAACAACTGGCCGCCGCACACGAA
CTCATTGACCGTGGGCGCGCCGAGGTCGTGGTGGTCTCGCTTGGATCTCAGGGCGCGCTA
TTGGCCACACGACATGCGAGCCATCGATTTTCGTCGATTCCGATGACCGCGGTTAGCGGT
GTCGGCGCCGGCGACGCGATGGTGGCCGCGATTACCGTGGGCCTCAGCCGTGGCTGGTCG
CTCATCAAGTCCGTTCGCTTGGGAAACGCGGCAGGTGCAGCCATGCTGCTGACGCCAGGC
ACCGCGGCCTGCAATCGCGACGATGTGGAGAGGTTCTTCGAGCTGGCGGCCGAACCCACC
GAAGTCGGGCAGGATCAATACGTTTGGCACCCGATCGTTAACCCGGAAGCCTCGCCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv3133c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. HD. Park, KM. Guinn et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 2003
Term	EC:2.7.1.11 6-phosphofructokinase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011