Rv0129c - secreted fibronectin-binding protein C antigen 85-C fbpC


Protein Domains

Gene Information
LocusRv0129c
SymbolfbpC
Gene Namesecreted fibronectin-binding protein C antigen 85-C fbpC
Location156578 - 157600 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1023 bp
Protein:341 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
Search Google Scholar
Orthologs
Orthogroup Number22427
Related GenesMAP3531c MAV_5183 ML2655 MT0137 MUL_4793
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv0129c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv2069activeashwinigbhat2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionRegulatory Rv2069activepriti.priety2012-10-05
Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
structural analysis
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
structural analysis
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
structural analysis
authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
structural analysis
authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
structural analysis
authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
structural analysis
authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
structural analysis
authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
structural analysis
authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
structural analysis
authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
structural analysis
authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
Spectrophometric assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
Spectrophometric assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,N. Matluk,JA. Rochira,A. Karaczyn,T. Adams,JM. Verdi A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. BMC Biol. 2010
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,G. Kumar,PK. Dagur,M. Singh,VS. Yadav,R. Dayal,HB. Singh,VM. Katoch,U. Sengupta,B. Joshi Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand. J. Immunol. 2008
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,E. Lozes,K. Huygen,J. Content,O. Denis,DL. Montgomery,AM. Yawman,P. Vandenbussche,JP. Van Vooren,A. Drowart,JB. Ulmer,MA. Liu Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997
InteractionPhysicalInteraction Rv1886cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
InteractionPhysicalInteraction Rv3804cactiveprabhakarsmail2012-10-05
Spectrophometric assay
authors,DR. Ronning,T. Klabunde,GS. Besra,VD. Vissa,JT. Belisle,JC. Sacchettini Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Biol. 2000
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Namemycolyltransferase 85C; INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
Mycolic acid processing
Namemycolyltransferase 85C; INVOLVED IN CELL WALL MYCOLOYLATIONactivemjackson2012-10-05
Mycolic acid processing
SymbolAg85Cactivejlew2012-03-07
Tat substrate. Demonstrated by experimental verification that four secreted proteins from Mtb carrying putative Tat signals are bona fide Tat substrates
M. Marrichi, L. Camacho et al. Genetic Toggling of Alkaline Phosphatase Folding Reveals Signal Peptides for All Major Modes of Transport across the Inner Membrane of Bacteria. J. Biol. Chem. 2008
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from its native host
authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from its native host
authors,JT. Belisle,VD. Vissa,T. Sievert,K. Takayama,PJ. Brennan,GS. Besra Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
authors,M. Jackson,C. Raynaud,MA. Lanéelle,C. Guilhot,C. Laurent-Winter,D. Ensergueix,B. Gicquel,M. Daffé Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope. Mol. Microbiol. 1999
TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
authors,M. Jackson,C. Raynaud,MA. Lanéelle,C. Guilhot,C. Laurent-Winter,D. Ensergueix,B. Gicquel,M. Daffé Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope. Mol. Microbiol. 1999
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactiveextern:JZUCKER2012-03-06
Inferred from experiment
V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
TermEC:2.3.1.122 Trehalose O-mycolyltransferase. - NRactiveextern:JZUCKER2012-03-06
Inferred from experiment
V. Puech, C. Guilhot et al. Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol. Microbiol. 2002
TermEC:2.3.1.- Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
authors,DC. Crick,S. Mahapatra,PJ. Brennan Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis. Glycobiology 2001