Rv2875 - major secreted immunogenic protein mpt70


Protein Domains

Gene Information
LocusRv2875
Symbolmpt70
Gene Namemajor secreted immunogenic protein mpt70
Location3187030 - 3187611 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:582 bp
Protein:194 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number13869
Related GenesCE0063 Mkms_2086 Mkms_2087 Mkms_4153 Mmcs_2040 Mmcs_2041 Mmcs_4077 MSMEG_5196 MT2940 MT2943 Mvan_2258 Mvan_2259 Mvan_4586 Rv2873
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv2875
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv0445cactiveshahanup862012-10-05
Affinity purification (Physical interaction)
authors,S. Rodrigue,J. Brodeur,PE. Jacques,AL. Gervais,R. Brzezinski,L. Gaudreau Identification of mycobacterial sigma factor binding sites by chromatin immunoprecipitation assays. J. Bacteriol. 2007
InteractionRegulatory Rv0445cactiveshahanup862012-10-05
Affinity purification (Physical interaction)
F. Veyrier, B. Saïd-Salim et al. Evolution of the mycobacterial SigK regulon. J. Bacteriol. 2008
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Miura,S. Nagai,M. Kinomoto,S. Haga,T. Tokunaga Comparative studies with various substrains of Mycobacterium bovis BCG on the production of an antigenic protein, MPB70. Infect. Immun. 1983
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Miura,S. Nagai,M. Kinomoto,S. Haga,T. Tokunaga Comparative studies with various substrains of Mycobacterium bovis BCG on the production of an antigenic protein, MPB70. Infect. Immun. 1983
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Miura,S. Nagai,M. Kinomoto,S. Haga,T. Tokunaga Comparative studies with various substrains of Mycobacterium bovis BCG on the production of an antigenic protein, MPB70. Infect. Immun. 1983
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,KA. Lightbody,RM. Girvin,DP. Mackie,SD. Neill,JM. Pollock T-cell recognition of mycobacterial proteins MPB70 and MPB64 in cattle immunized with antigen and infected with Mycobacterium bovis. Scand. J. Immunol. 1998
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,KA. Lightbody,RM. Girvin,DP. Mackie,SD. Neill,JM. Pollock T-cell recognition of mycobacterial proteins MPB70 and MPB64 in cattle immunized with antigen and infected with Mycobacterium bovis. Scand. J. Immunol. 1998
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,KA. Lightbody,RM. Girvin,DP. Mackie,SD. Neill,JM. Pollock T-cell recognition of mycobacterial proteins MPB70 and MPB64 in cattle immunized with antigen and infected with Mycobacterium bovis. Scand. J. Immunol. 1998
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,JM. Pollock,AJ. Douglas,DP. Mackie,SD. Neill Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19,000 MW and MPB57. Immunology 1994
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,JM. Pollock,AJ. Douglas,DP. Mackie,SD. Neill Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19,000 MW and MPB57. Immunology 1994
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,JM. Pollock,AJ. Douglas,DP. Mackie,SD. Neill Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19,000 MW and MPB57. Immunology 1994
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,HG. Wiker,KP. Lyashchenko,AM. Aksoy,KA. Lightbody,JM. Pollock,SV. Komissarenko,SO. Bobrovnik,IN. Kolesnikova,LO. Mykhalsky,ML. Gennaro,M. Harboe Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,HG. Wiker,KP. Lyashchenko,AM. Aksoy,KA. Lightbody,JM. Pollock,SV. Komissarenko,SO. Bobrovnik,IN. Kolesnikova,LO. Mykhalsky,ML. Gennaro,M. Harboe Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,HG. Wiker,KP. Lyashchenko,AM. Aksoy,KA. Lightbody,JM. Pollock,SV. Komissarenko,SO. Bobrovnik,IN. Kolesnikova,LO. Mykhalsky,ML. Gennaro,M. Harboe Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
W. Vosloo, P. Tippoo et al. Characterisation of a lipoprotein in Mycobacterium bovis (BCG) with sequence similarity to the secreted protein MPB70. Gene 1997
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
W. Vosloo, P. Tippoo et al. Characterisation of a lipoprotein in Mycobacterium bovis (BCG) with sequence similarity to the secreted protein MPB70. Gene 1997
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
W. Vosloo, P. Tippoo et al. Characterisation of a lipoprotein in Mycobacterium bovis (BCG) with sequence similarity to the secreted protein MPB70. Gene 1997
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
M. Harboe, HG. Wiker et al. MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
M. Harboe, HG. Wiker et al. MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
M. Harboe, HG. Wiker et al. MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infect. Immun. 1998
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,M. Harboe,S. Nagai MPB70, a unique antigen of Mycobacterium bovis BCG. Am. Rev. Respir. Dis. 1984
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,M. Harboe,S. Nagai MPB70, a unique antigen of Mycobacterium bovis BCG. Am. Rev. Respir. Dis. 1984
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,M. Harboe,S. Nagai MPB70, a unique antigen of Mycobacterium bovis BCG. Am. Rev. Respir. Dis. 1984
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Terasaka,R. Yamaguchi,K. Matsuo,A. Yamazaki,S. Nagai,T. Yamada Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG. FEMS Microbiol. Lett. 1989
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Terasaka,R. Yamaguchi,K. Matsuo,A. Yamazaki,S. Nagai,T. Yamada Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG. FEMS Microbiol. Lett. 1989
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,K. Terasaka,R. Yamaguchi,K. Matsuo,A. Yamazaki,S. Nagai,T. Yamada Complete nucleotide sequence of immunogenic protein MPB70 from Mycobacterium bovis BCG. FEMS Microbiol. Lett. 1989
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,MD. Carr,MJ. Bloemink,E. Dentten,AO. Whelan,SV. Gordon,G. Kelly,TA. Frenkiel,RG. Hewinson,RA. Williamson Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease. J. Biol. Chem. 2003
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,MD. Carr,MJ. Bloemink,E. Dentten,AO. Whelan,SV. Gordon,G. Kelly,TA. Frenkiel,RG. Hewinson,RA. Williamson Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease. J. Biol. Chem. 2003
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
authors,MD. Carr,MJ. Bloemink,E. Dentten,AO. Whelan,SV. Gordon,G. Kelly,TA. Frenkiel,RG. Hewinson,RA. Williamson Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease. J. Biol. Chem. 2003
InteractionPhysicalInteraction Rv2872activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
MD. Juárez, A. Torres et al. Characterization of the Mycobacterium tuberculosis region containing the mpt83 and mpt70 genes. FEMS Microbiol. Lett. 2001
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
MD. Juárez, A. Torres et al. Characterization of the Mycobacterium tuberculosis region containing the mpt83 and mpt70 genes. FEMS Microbiol. Lett. 2001
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
MD. Juárez, A. Torres et al. Characterization of the Mycobacterium tuberculosis region containing the mpt83 and mpt70 genes. FEMS Microbiol. Lett. 2001
InteractionPhysicalInteraction Rv2874activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
MD. Juárez, A. Torres et al. Characterization of the Mycobacterium tuberculosis region containing the mpt83 and mpt70 genes. FEMS Microbiol. Lett. 2001
InteractionPhysicalInteraction Rv2873activepriti.priety2012-10-05
Gene Neighborhood (Functional linkage)
MD. Juárez, A. Torres et al. Characterization of the Mycobacterium tuberculosis region containing the mpt83 and mpt70 genes. FEMS Microbiol. Lett. 2001