Rv2610c - alpha-mannosyltransferase pimA

Expression: Most Significant Conditions for Rv2610c

Protein Domains

Gene Information
Locus	Rv2610c
Symbol	pimA
Gene Name	alpha-mannosyltransferase pimA
Location	2937865 - 2939001 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1137 bp Protein:379 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	30149
Related Genes	Acel_1353 CE1781 cg1876 DIP1384 jk1062 MAP2712c MAV_3486 Mkms_2293 ML0452 Mmcs_2246 MSMEG_2935 MT2685 MUL_3252 Mvan_2562 nfa37080 SAV6828
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2610c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2610c Transcript 1
MRIGMICPYSFDVPGGVQSHVLQLAEVMRTRGHLVSVLAPASPHAALPDYFVSGGRAVPI
PYNGSVARLRFGPATHRKVKKWLAHGDFDVLHLHEPNAPSLSMLALNIAEGPIVATFHTS
TTKSLTLTVFQGILRPMHEKIVGRIAVSDLARRWQMEALGSDAVEIPNGVDVDSFASAAR
LDGYPRQGKTVLFLGRYDEPRKGMAVLLDALPKVVQRFPDVQLLIVGHGDADQLRGQAGR
LAAHLRFLGQVDDAGKASAMRSADVYCAPNTGGESFGIVLVEAMAAGTAVVASDLDAFRR
VLRDGEVGHLVPVDPPDLQAAALADGLIAVLENDVLRERYVAAGNAAVRRYDWSVVASQI
MRVYETVAGSGAKVQVAS*

Genomic Sequence

>Rv2610c
ATGCGGATCGGCATGATTTGTCCGTACTCGTTCGACGTCCCGGGCGGGGTGCAGTCGCAT
GTGCTACAGCTTGCCGAGGTGATGCGCACCCGCGGCCACTTGGTCAGTGTGCTCGCGCCG
GCCTCCCCGCATGCCGCACTGCCTGATTACTTTGTCTCCGGTGGTAGGGCGGTTCCGATT
CCCTACAACGGCTCGGTGGCCCGGCTGCGGTTCGGTCCGGCGACCCACCGCAAGGTCAAA
AAGTGGCTTGCGCATGGTGATTTCGACGTACTGCATCTACACGAGCCGAATGCGCCGAGC
CTGTCGATGCTGGCCCTGAACATTGCCGAGGGCCCGATTGTGGCGACATTTCACACCTCG
ACCACCAAGTCGCTGACGCTGACGGTGTTCCAGGGCATTCTGCGGCCCATGCACGAGAAG
ATCGTCGGCCGGATCGCGGTGTCCGACCTAGCCCGGCGCTGGCAGATGGAGGCGTTGGGA
TCCGATGCGGTGGAGATCCCCAATGGGGTGGACGTTGATTCCTTCGCCTCGGCAGCGCGG
CTGGACGGGTACCCGCGCCAGGGTAAAACGGTGTTGTTCCTGGGTCGCTACGACGAGCCC
CGCAAGGGCATGGCCGTTTTGCTCGACGCGCTGCCGAAGGTGGTGCAGCGGTTTCCGGAT
GTCCAGCTACTGATCGTCGGCCACGGCGACGCCGACCAGTTGCGCGGCCAGGCGGGCCGT
TTGGCGGCGCACCTGCGCTTTCTGGGTCAGGTGGACGACGCCGGAAAAGCTTCGGCGATG
CGCAGCGCCGACGTCTACTGTGCGCCCAACACCGGCGGTGAGAGTTTCGGCATTGTGCTG
GTCGAAGCGATGGCCGCCGGCACTGCGGTGGTGGCCAGCGACCTCGACGCCTTCCGGCGT
GTGCTGCGCGACGGTGAGGTCGGGCACCTGGTGCCGGTGGACCCGCCAGACTTGCAGGCC
GCCGCGTTGGCCGATGGACTGATTGCGGTGCTGGAGAACGATGTCCTGCGGGAGCGCTAT
GTGGCGGCCGGCAACGCGGCCGTCCGCCGGTATGACTGGTCGGTGGTGGCCAGCCAGATC
ATGCGAGTGTACGAGACGGTCGCCGGGTCGGGCGCCAAGGTTCAGGTGGCCAGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:G16MTM1 Glycolipid 1,6-alpha-D-mannosyltransferase - IPI	active	njamshidi	2012-10-05
	known to occur physiologically see for example PMID: 12851411 J. Korduláková, M. Gilleron et al. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J. Biol. Chem. 2003
Term	EC:2.4.1.131 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase. - IPI	active	njamshidi	2012-10-05
	known to occur physiologically see for example PMID: 12851411 J. Korduláková, M. Gilleron et al. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J. Biol. Chem. 2003
Term	TBRXN:G16MTM1 Glycolipid 1,6-alpha-D-mannosyltransferase - ISS	active	njamshidi	2012-10-05
	known to occur physiologically see for example PMID: 12851411 J. Korduláková, M. Gilleron et al. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J. Biol. Chem. 2003
Term	EC:2.4.1.131 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase. - ISS	active	njamshidi	2012-10-05
	known to occur physiologically see for example PMID: 12851411 J. Korduláková, M. Gilleron et al. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J. Biol. Chem. 2003
Interaction	PhysicalInteraction Rv2611c	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,PJ. Brennan Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb) 2003
Interaction	PhysicalInteraction Rv2611c	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,PJ. Brennan Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb) 2003
Interaction	PhysicalInteraction Rv2609c	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,PJ. Brennan Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb) 2003
Interaction	PhysicalInteraction Rv2609c	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,PJ. Brennan Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb) 2003
Name	GDP-Man-dependent alpha-1,2-phosphatidylinositol mannosyltransferase; essential gene in M. tb (Barilone, Stadthagen, Jackson; unpublished result)	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Name	GDP-Man-dependent alpha-1,2-phosphatidylinositol mannosyltransferase; essential gene in M. tb (Barilone, Stadthagen, Jackson; unpublished result)	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,2-phosphatidylinositol mannosyltransferase (phenotypic [mycobacterial recombinant strains]; enzymatic); essential gene in M. tb (Barilone, Stadthagen, Jackson; unpublished) ME. Guerin, D. Kaur et al. New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. J. Biol. Chem. 2009
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	GDP-Man-dependent alpha-1,2-phosphatidylinositol mannosyltransferase (phenotypic [mycobacterial recombinant strains]; enzymatic); essential gene in M. tb (Barilone, Stadthagen, Jackson; unpublished) J. Korduláková, M. Gilleron et al. Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. J. Biol. Chem. 2002